什么是Caspase级联反应生化当中经常提到CASPASE级联反应,究竟什么是CASPASE级联反应,它有多少条通路,每条通路之间的关系是什么
来源:学生作业帮助网 编辑:作业帮 时间:2024/06/30 05:32:19
![什么是Caspase级联反应生化当中经常提到CASPASE级联反应,究竟什么是CASPASE级联反应,它有多少条通路,每条通路之间的关系是什么](/uploads/image/z/3650901-69-1.jpg?t=%E4%BB%80%E4%B9%88%E6%98%AFCaspase%E7%BA%A7%E8%81%94%E5%8F%8D%E5%BA%94%E7%94%9F%E5%8C%96%E5%BD%93%E4%B8%AD%E7%BB%8F%E5%B8%B8%E6%8F%90%E5%88%B0CASPASE%E7%BA%A7%E8%81%94%E5%8F%8D%E5%BA%94%2C%E7%A9%B6%E7%AB%9F%E4%BB%80%E4%B9%88%E6%98%AFCASPASE%E7%BA%A7%E8%81%94%E5%8F%8D%E5%BA%94%2C%E5%AE%83%E6%9C%89%E5%A4%9A%E5%B0%91%E6%9D%A1%E9%80%9A%E8%B7%AF%2C%E6%AF%8F%E6%9D%A1%E9%80%9A%E8%B7%AF%E4%B9%8B%E9%97%B4%E7%9A%84%E5%85%B3%E7%B3%BB%E6%98%AF%E4%BB%80%E4%B9%88)
什么是Caspase级联反应生化当中经常提到CASPASE级联反应,究竟什么是CASPASE级联反应,它有多少条通路,每条通路之间的关系是什么
什么是Caspase级联反应
生化当中经常提到CASPASE级联反应,究竟什么是CASPASE级联反应,它有多少条通路,每条通路之间的关系是什么
什么是Caspase级联反应生化当中经常提到CASPASE级联反应,究竟什么是CASPASE级联反应,它有多少条通路,每条通路之间的关系是什么
Caspase 是一类与凋亡密切相关的蛋白水解酶家族,以Caspase前体酶原的形式存在大多后生动物的细胞中.
Caspase在凋亡信号的作用下首先激活启动型Caspase引发Caspase级联反应(Caspase Cascade),然后通过活化的执行型Caspase裂解特异性底物导致细胞凋亡.Caspase的活化是导致细胞凋亡的中心环节,位于Caspase级联反应上游的启动型Caspase的和下游的执行型Caspase有着明显不同的活化机制.
有一个英文的简单的描述:
Caspase Cascade
Apoptosis or programmed cell death is triggered by a variety of stimuli,including cell surface receptors like FAS,the mitochondrial response to stress,and factors released from cytotoxic T cells.The caspases comprise a class of cysteine proteases many members of which are involved in apoptosis.The caspases convey the apoptotic signal in a proteolytic cascade,with caspases cleaving and activating other caspases that subsequently degrade cellular targets that lead to cell death.The activating caspases include caspase-8 and caspase-9.Caspase-8 is the initial caspase activated in response to receptors with a death domain that interacts with FADD.The mitochondrial stress pathway begins with the release of cytochrome c from mitochondria,which then interacts with Apaf-1,causing self-cleavage and activation of caspase-9.The effector caspases,caspase-3,-6 and-7 are downstream of the activator caspases and act to cleave various cellular targets.Granzyme B and perforin,proteins released by cytotoxic T cells,induce apoptosis in target cells by forming transmembrane pores and triggering apoptosis,perhaps through cleavage of caspases.Caspase independent mechanisms of granzyme B-mediated apoptosis have been suggested.